Since Universal GUI 2025.2.13 (rc1) fields with ‘Look-up has popup’ will become clickable in the (non-edit-mode) grid to open the lookup. This feature would be ever better if a user could right-click on the link to choose how to open the lookup (similar to a hyperlink on a website).
-Open as popup
-Open as new document
-Open as new browser tab
-Open as new browser window

Bonus points if the default way of opening (left-click) is configurable for each lookup in the SF.